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Laura Ellwein Fix



Ph.D. Applied Mathematics with concentration in Physiology, 2008.

North Carolina State University, Raleigh NC

“Cardiovascular and Respiratory Regulation, Modeling and Parameter Estimation.”

Advisor: Mette S. Olufsen.

M.S. Applied Mathematics with concentration in Computational Mathematics, 2005.

North Carolina State University, Raleigh NC

B.S. in Chemical Engineering, 1999.

University of Wisconsin, Madison WI


I develop mathematical models to simulate and analyze transport phenomena in cardiorespiratory physiology. My primary focus is on lumped parameter models describing system level dynamics and regulation, and I also have experience with distributed parameter models of local hemodynamics. My work is interdisciplinary and I collaborate with researchers in biomedical engineering, medicine, and exercise science.


Ellwein L, Samyn M, Danduran M, Schindler-Ivens S, Liebham S, LaDisa Jr. JF. (2016) Toward translating near-infrared spectroscopy oxygen saturation data for the non-invasive prediction of spatial and temporal hemodynamics during exercise. Biomech Model Mechanobiol, doi: 10.1007/s10237-016-0803-4

Ellwein L, Marks DS, Migrino RQ, Foley WD, Sherman S, LaDisa JF Jr. (2015) Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. Cathet Cardiovasc Intervent, doi: 10.1002/ccd.26247.

Ford Versypt AN, Makrides E, Arciero J, Ellwein L, Layton AT. (2015) Bifurcation study of blood flow control in the kidney. Math Biosci, 263:169-179.

Quam DJ, Gundert TJ, Migrino RQ, Otake H, Ellwein L, Hayden P, LaDisa JF, Jr. (2015) Immersive Visualization for Enhanced Computational Fluid Dynamics Analysis. J Biomech Eng, 137(3):031004.

Arciero J, Ellwein L, Ford Versypt AN, Makrides E, Layton AT. (2014) Modeling blood flow control in the kidney. In: Jackson T, Radunskaya A (Eds) Applications of Dynamical Systems in Biology and Medicine (Vol 158, pp.55-73). The IMA Volumes in Mathematics and its Applications: Springer New York.

Ellwein LM, LaDisa JF, Jr., Leibham S, Schindler-Ivens S, Samyn M. Quantification of thoracic aorta blood flow by magnetic resonance imaging during supine cycling exercise of increasing intensity. J Cardiov Magn Reson, 15(Suppl 1):P239, 2013.

Ellwein LM, Pope S, Xie A, Batzel JJ, Kelley CT, Olufsen MS. Patient-specific modeling of cardiovascular and respiratory dynamics during hypercapnia. Math Biosci, 241:56-72, 2013.

Wendell DC, Samyn MM, Cava JR, Ellwein LM, Krolikowski MM, Gandy KL, Pelech AN, Shadden SC, LaDisa JF. Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys, 35(6):723-735, 2013.

Ellwein LM, Otake H, Gundert TJ, Koo B-K, Shinke T, Honda Y, Shite J, Ladisa JF, Jr. Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovasc Eng Technol, 2(3): 212-227, 2011.

Pope SR, Ellwein LM, Zapata CL, Novak V, Kelley CT, Olufsen MS. Estimation and identification of parameters in a lumped cerebrovascular model. Math Biosci Eng, 6(1):93-115, 2009.

Ellwein LM, Tran H, Zapata CL, Novak V, Olufsen MS. Sensitivity analysis and model assessment: mathematical models for arterial blood flow and blood pressure. J Cardio Eng, 8(2):94-108, 2008.


Society of Industrial and Applied Mathematics (SIAM)

Association of Women in Mathematics (AWM)