### Mathematical modeling of intercellular calcium dynamics

Prof Gregory D. Smith

College of William & Mary

Friday, November 13, 2:00-2:50

Academic Learning Commons 2100

In most cell types the endoplasmic reticulum (ER) has integrative and

regenerative properties analogous to the excitable membranes of neurons.

Considerable insight into ER “calcium excitability” has been obtained through

the development of mathematical models of calcium signaling that are based

on molecular mechanisms and physical principles.

This colloquium will present an overview of the dynamics of local and global

calcium signaling in living cells and how these are studied using a variety of

mathematical modeling approaches. Of particular interest are the calcium

signals known as “calcium sparks” that couple electrical excitation to muscle

contraction during the cardiac cycle.