# Laura Ellwein Fix, Ph.D.

Associate Professor

## Education

- Ph.D. Applied Mathematics with concentration in Physiology, 2008, North Carolina State University, [“Cardiovascular and Respiratory Regulation, Modeling and Parameter Estimation"; Adviser: Mette S. Olufsen]
- M.S. Applied Mathematics with concentration in Computational Mathematics, 2005, North Carolina State University
- B.S. in Chemical Engineering, 1999, University of Wisconsin, Madison

## Research Interests

Fix develops mathematical models to simulate and analyze transport phenomena in cardiorespiratory physiology. Her primary focus is on lumped parameter models describing system level dynamics and regulation, and she also has experience with distributed parameter models of local hemodynamics. Her work is interdisciplinary and she collaborates with researchers in biomedical engineering, medicine and exercise science.

## Select Publications

- Ellwein L, Samyn M, Danduran M, Schindler-Ivens S, Liebham S, LaDisa Jr. JF. (2016) Toward translating near-infrared spectroscopy oxygen saturation data for the non-invasive prediction of spatial and temporal hemodynamics during exercise. Biomech Model Mechanobiol, doi: 10.1007/s10237-016-0803-4
- Ellwein L, Marks DS, Migrino RQ, Foley WD, Sherman S, LaDisa JF Jr. (2015) Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. Cathet Cardiovasc Intervent, doi: 10.1002/ccd.26247.
- Ford Versypt AN, Makrides E, Arciero J, Ellwein L, Layton AT. (2015) Bifurcation study of blood flow control in the kidney. Math Biosci, 263:169-179.
- Quam DJ, Gundert TJ, Migrino RQ, Otake H, Ellwein L, Hayden P, LaDisa JF, Jr. (2015) Immersive Visualization for Enhanced Computational Fluid Dynamics Analysis. J Biomech Eng, 137(3):031004.
- Arciero J, Ellwein L, Ford Versypt AN, Makrides E, Layton AT. (2014) Modeling blood flow control in the kidney. In: Jackson T, Radunskaya A (Eds) Applications of Dynamical Systems in Biology and Medicine (Vol 158, pp.55-73). The IMA Volumes in Mathematics and its Applications: Springer New York.
- Ellwein LM, LaDisa JF, Jr., Leibham S, Schindler-Ivens S, Samyn M. Quantification of thoracic aorta blood flow by magnetic resonance imaging during supine cycling exercise of increasing intensity. J Cardiov Magn Reson, 15(Suppl 1):P239, 2013.
- Ellwein LM, Pope S, Xie A, Batzel JJ, Kelley CT, Olufsen MS. Patient-specific modeling of cardiovascular and respiratory dynamics during hypercapnia. Math Biosci, 241:56-72, 2013.
- Wendell DC, Samyn MM, Cava JR, Ellwein LM, Krolikowski MM, Gandy KL, Pelech AN, Shadden SC, LaDisa JF. Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys, 35(6):723-735, 2013.
- Ellwein LM, Otake H, Gundert TJ, Koo B-K, Shinke T, Honda Y, Shite J, Ladisa JF, Jr. Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovasc Eng Technol, 2(3): 212-227, 2011.
- Pope SR, Ellwein LM, Zapata CL, Novak V, Kelley CT, Olufsen MS. Estimation and identification of parameters in a lumped cerebrovascular model. Math Biosci Eng, 6(1):93-115, 2009.
- Ellwein LM, Tran H, Zapata CL, Novak V, Olufsen MS. Sensitivity analysis and model assessment: mathematical models for arterial blood flow and blood pressure. J Cardio Eng, 8(2):94-108, 2008.

## Affiliations

- Society of Industrial and Applied Mathematics (SIAM)
- Association of Women in Mathematics (AWM)