# Angela Reynolds, Ph.D.

Professor

Ph.D. Program Director

## Education

- Ph.D. in Mathematics, University of Pittsburgh, 2008 [Title: "Mathematical Models of Acute Inflammation and a Full Lung Model of Gas Exchange with Inflammatory Stress"; Adviser: Dr. G. Bard Ermentrout]
- B.S in Mathematics with a minor in Asian Studies, Loyola College of Maryland, 2002

## Research Interests

Reynolds' research area focuses on the role of inflammation in the wound healing and other diseases. Currently, her main projects focus on inflammation in the lung and role of the inflammatory stage of wound healing. She collaborates with mechanical and biomedical engineering and medicine to develop a multi-scale model for Ventilator-Associated Lung Injury (VALI) which accounts for inflammation triggered by mechanical ventilation. Understanding the interplay between the inflammatory and repair phases of healing is key to determining more effective treatment protocols. In order to research this aspect of wound healing, we are developing an ordinary differential equations model for the accumulation of collagen in a wound with systemic mediators. This work is a collaboration between mathematics, electrical and computer engineering and medicine.

## Select Publications

- Sarah B. Minucci, Rebecca L. Heise, F. J. Kamga Gninzeko, Michael S. Valentine, Angela M. Reynolds, Mathematical modeling of ventilator-induced lung inflammation, Journal of Theorectical Biology, October 2021.
- Sarah B. Minucci, Rebecca L. Heise, Angela M. Reynolds, Review of Mathematical Modeling of the Inflammatory

Response in Lung Infections and Injuries, Front. Appl. Math. Stat., 26 August 2020 - Heyrim Cho, Allison L. Lewis, Kathleen M. Storey, Rachel Jennings, Blerta Shtylla, Angela M. Reynolds, and Helen M. Byrne, A Framework for Performing Data-Driven Modeling of Tumor Growth with Radiotherapy Treatment, Accepted, Nov 2019 as book chapter to Springer’s WBIO series.
- Torres M, Wang J, Yannie PJ, Ghosh S, Segal RA, Reynolds AM. Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization. PLoS Comput Biol. 2019 Jul;15(7):e1007172. doi: 10.1371/journal.pcbi.1007172. eCollection 2019 Jul. PubMed PMID: 31365522; PubMed Central PMCID: PMC6690555.
- Aghasafari P, Heise RL, Reynolds A, Pidaparti RM. Aging Effects on Alveolar Sacs Under Mechanical Ventilation. J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):139-146. doi: 10.1093/gerona/gly097. PubMed PMID: 29746613; PubMed Central PMCID: PMC6333941
- M. S. Valentine, P. A. Link, J. A. Herbert, F. J. Kamga Gninzeko, M. B. Schneck, K. Shankar, J. Nkwocha, A. M. Reynolds, R. L. Heise, Inflammation and Monocyte Recruitment Due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular, Chaperone 4-Phenylbutyrate, Cellular and Molecular Bioengineering, available online 19 June 2018

## Affiliations

- Pi Mu Epsilon- National Mathematics Honors society (PME)
- Society of Mathematical Biology (SMB)
- Society of Industrial and Applied Mathematics (SIAM)
- Association for Women in Mathematics (AWM)
- Beta Beta Beta- National Biology Honors society (Tri Beta)

## Professional Activities

- Editorial Board, Letters in Biomath (2014-present)
- Reviewer for funding agencies (NIH, Kentucky Science and Engineering Foundation)
- Review for journals (JTB, JCRC)