In this talk, I will present recent advances in modeling the electric response of biological cells.
A nerve impulse is the propagation of a membrane potential along a nerve in response to various stimuli. To simulate the electrical behavior of biological tissues, we rely on partial differential equations. However, solving these equations analytically is rarely feasible—especially when a nerve bundle contains a large number of axons, which poses significant challenges even for modern numerical methods.
In this presentation, I will outline several electrophysiological models and explain how to derive more computationally tractable macroscopic equations. From a mathematical perspective, this leads to coupled systems of nonlinear evolution equations. Because the diameter of axons in a bundle is typically much smaller than the length of the nerve, we introduce a small parameter representing this ratio and seek an asymptotic approximation of the electric potential as this parameter tends to zero. The approach combines asymptotic analysis, homogenization techniques, and the method of monotone operators to handle the passage to the limit. I will provide a brief introduction to homogenization and focus primarily on the analytical aspects of the models rather than their numerical implementation. This work is done in collaboration with C. Jerez-Hanckes, I. Martinez, V.Rybalko, and A. Rybalko.